Sordarin je účinné antimykotikum s unikátním mechanismem účinku. Inhibuje syntézu proteinů u mikroorganismů, jako je např. kvasinka Candida albicans (Dominguez et al. 1999). Inhibuje aktivitu GTPázy a jeho cílovou molekulou je elongační faktor 2 (EF-2) (Dominguez et al. 1998), na němž se nachází vysokoafinitní vazebné místo pro sordarin (Dominguez a Martín 2001). EF-2 je esenciální protein katalyzující ribosomální translokaci při proteosyntéze (Andersen eta l. 2003) a je vysoce konzervativní strukturou u všech eukaryot (Justice et al. 1998; Domingue a Martíz 1998). Objev EF-2 byl velmi významný, protože tento protein se stal významným cílem pro zcela novou rodinu antimykotik (Capa et al. 1998) a během rátké doby byla syntetizována řada biologicky účinných derivátů (Arribas et al. 2002; Bueno et al. 2002a,b; Castro et al. 2002; Serrano-Wu et al. 2002; Hanadate et al. 2009; Schulé et al. 2009). Samotný sordarin byl také připraven totální syntézou (Chiba et al. 2006).
     Sordariny a jejich polosyntetické deriváty jsou účinnými antimykotiky u řady patogenních kvasinek (Herreros et al. 1998, 2001; Tse et al. 1998; Graybill et al. 1999), kandidóz, aspergilóz a pneumocystóz (Martinez et al. 2000). Sordariny se staly významnými nástroji molekulárních biologů při studiu proteosyntézy a pomohly odhalit složité biochemické reakce odehrávající se na ribozomech při přepisu genetické informace do syntetizovaného proteinu (Santos a Ballesta 2005; Søe et al. 2007; Botet et al. 2008).

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